Box plots of mycophenolic acid (MPA) exposure as measured by the AUC with the
current target range (dotted lines)12–15 (A)
and the effect as measured by inosine monophosphate dehydrogenase (IMPDH)
activity and inhibition (B) over time: (0) pretransplant, (1) early
posttransplant, (2) prior to discharge, and (3) at stable mycophenolate mofetil
(MMF) treatment. The bottom and top of the box represent the 25th and 75th
percentiles, respectively. The 50th percentile (median) is represented by the
band near the middle of the box. The ends of the whiskers represent the minimum
and maximum data points. Data points represented by a star are considered
outliers, defined as outside 1.5 interquartile range of the highest value of all
values except the outlier.