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. Author manuscript; available in PMC: 2013 Sep 11.
Published in final edited form as: J Clin Pharmacol. 2010 Apr 23;51(3):309–320. doi: 10.1177/0091270010368542

Figure 4.

Figure 4

The concentration-response relationship could be described by an inhibitory direct effect Emax model. The E0 and EC50 estimates were 6.2 nmol/h/mg protein (SE 0.65; 95% confidence interval [CI]: 4.9–7.5) and 0.97 mg/mL (SE 0.22; 95% CI: 0.55–1.41 mg/L), respectively, when Emax was fixed (value of 0) and is based here on 285 appropriately matched mycophenolic acid–inosine monophosphate dehydrogenase (MPA-IMPDH) data pairs out of 377 measurements. The mean observed baseline IMPDH activity of 6.4 nmol/h/mg protein (Table III) was close to the model-estimated E0.