Table III.
Pre- and Posttransplant IMPDH Activity Parameters Obtained, Expressed as nmol/h/mg Protein
| Pretransplant (Baseline
Before Dosing) |
Early Posttransplant
(1–3 Days) |
Prior to Discharge
(5–9 Days) |
Stable Period (Approximately
6 Months) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n = 19) | (n = 21) | (n = 19) | (n = 13) | |||||||||||||
| Range |
Range |
Range |
Range |
|||||||||||||
| Mean | Min | Max | SD | Mean | Min | Max | SD | Mean | Min | Max | SD | Mean | Min | Max | SD | |
| Age at transplant, y | 12.4 | 2.1 | 20.2 | 5.3 | 13.5 | 4.1 | 20.2 | 4.5 | 13.6 | 4.1 | 20.2 | 4.5 | 15.1 | 10.6 | 18.7 | 2.1 |
| Age group: ≥2 and <6/≥6 and <12/≥12 to 18 years | 4:2:13 | 3:1:17 | 3:0:16 | 0:1:12 | ||||||||||||
| Predose IMPDH activity, nmol/h/mg protein | 6.4 | 1.0 | 18.4 | 4.6 | 4.1 | 0.3 | 13.1 | 2.8 | 3.1 | 0.8 | 7.0 | 1.6 | 1.7 | 0.1 | 3.4 | 1.1 |
| Nadir IMPDH activity, nmol/h/mg proteina | 1.9 | 0.1 | 5.4 | 1.7 | 1.1 | 0.1 | 3.1 | 0.8 | 0.5 | 0.1 | 1.3 | 0.4 | ||||
| % Inhibition/ predose | 53 | 0 | 82 | 28 | 65 | 19 | 91 | 18 | 62 | 0 | 90 | 27 | ||||
| (n = 13) | (n = 12) | (n = 9) | ||||||||||||||
| % Inhibition/ baseline | 65 | –34 | 93 | 40 | 84 | 64 | 97 | 11 | 87 | 46 | 99 | 17 | ||||
Parameter values are reported as means with standard deviations (SD) and ranges. IMPDH, inosine monophosphate dehydrogenase.
a
Minimum IMPDH activity is defined as the lowest IMPDH activity observed after administration of a dose of mycophenolate mofetil.