Hematocrit (A), RVSP (B), and RV/LV+S (C) all have significant differences dependent on pressure, strain, and pressure-dependent on strain by 2-way ANOVA. Differences in individual values were determined using Tukey’s post hoc test. All values at 50 kPa are significantly different (p < .05) than the within-strain 85 kPa value. (A) Hematocrit in C57BL/6 is higher at 85 kPa than other strains (*) but increases less with 50 kPa hypoxia (§). Hematocrit in FVB/N at 50 kPa is less than in other strains (†). (B) RVSP at 85 kPA in C57BL/6 is significantly lower than in SV129 (*), but neither are different than FVB/N. RVSP at 85 kPa in C57BL/6 is lower than other strains (†), and increase in RVSP between 85 and 50 kPa is greater in SV129 than in other strains (§). (C) Right heart muscularization is lower at 85 kPa in C57BL/6 than FVB/N mice but neither is different than SV129. RV/LV+S is different at 50 kPa in all strains, and increase in RV/LV+S between pressures is lower in FVB/N than in other strains (†).