Table 1.
Top 5 canonical pathway results using Ingenuity Pathways Analysis (Ingenuity® Systems, www.ingenuity.com)
| Baseline-up | Baseline-down | 36 month-up | 36 month-down |
|---|---|---|---|
| B cell development (7.66 × 10E-04) | Oxidative phosphorylation (3.22 × 10E-09) | Interferon signaling (2.72 × 10E-07) | Mitochondrial dysfunction (5.54 × 10E-06) |
| Phospholipase C signaling (8.16 × 10E-04) | Mitochondrial dysfunction (9.18 × 10E-08) | Calcium-induced T lymphocyte apoptosis (1.28 × 10E-04) | Oxidative phosphorylation (1.02 × 10E-05) |
| Calcium-induced T lymphocyte apoptosis (3.4 × 10E-03) | Ubiquinone biosynthesis (8.85 × 10E-05) | Activation of IRF by cytosolic pattern recognition receptors (2.2 × 10E-04) | Toll-like receptor signaling (6.60 × 10E-04) |
| Aminoacyl tRNA biosynthesis (5.65 × 10E-03) | NRF2-mediated oxidative stress response (1.15 × 10E-03) | Nur77 signaling in T lymphocytes (5.89 × 10E-04) | Cdc42 signaling (8.31 × 10E-03) |
| CTLA4 signaling in cytotoxic T lymphocytes (5.77 × 10E-03) | Protein ubiquitination pathway (5.24 × 10E-03) | Role of pattern recognition receptors in recognition of bacteria and viruses (6.07 × 10E-04) | Ubiquinone biosynthesis (1.14 × 10E-02) |
Enrichment P values are in parentheses