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. Author manuscript; available in PMC: 2013 Sep 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2011 Nov 21;51(5):1124–1137. doi: 10.1002/anie.201103110

Figure 3.

Figure 3

Structures of CrtM and SQS. a) S. aureus CrtM (green) with FSPP, Mg2+ superimposed on human SQS (orange): essential Asp residues and Mg2+ colored as in Fig. 1. b) Active site region in CrtM + FSPP (green, yellow), Mg2+. c) PSPP, Mg2+ (all in cyan) bound to CrtM, superimposed on FSPP/Mg2+ structure (in green/yellow/blue). d) Dehydrosqualene product (pink) bound to CrtM, superimposed on PSPP structure (cyan). S1 = allylic binding site; S2 = homoallylic binding site.