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. Author manuscript; available in PMC: 2013 Sep 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2011 Nov 21;51(5):1124–1137. doi: 10.1002/anie.201103110

Figure 7.

Figure 7

Modular structures of the 4Fe-4S cluster-containing proteins IspH and IspG. a) E. coli IspH showing the three helix/sheet domains surrounding the 4Fe-4S cluster in the “closed” form (which buries the Fe/S cluster). b) E. coli IspG showing an “open” structure. The 4Fe-4S cluster from one chain is thought to interact with the TIM barrel in the second chain to form the active site (black box). c) Superposition of the TIM barrel in E. coli IspG (orange) with B. anthracis dihydropteroate synthase (cyan). d) Superposition of the 4Fe-4S cluster domain in IspG with that in spinach nitrite reductase. The Cα rmsds in c,d are 2.4, 2.1 Å, respectively.