TABLE 1.

A brief list of characterized host proteins and their functions in plant virus replication.

Virus	Protein name	Function Description	Proposed function	references
TBSV	Cdc34	Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex	component of the viral replicase complex; ubiquitinate p33 to enhance TBSV replication.	[4]
TBSV	Tef1/2	Translational elongation factor EF-1 alpha	component of the viral replicase complex; mutation of tef1/2 reduces TBSV replicase protein stability in vivo and viral replication.	[6]
TBSV	Tdh2/3	Glyceraldehyde-3-phosphate dehydrogenase	component of the viral replicase complex; helps the assymetric replication of TBSV.	[3,5]
TBSV	Ssa1/2	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family	component of the viral replicase complex; assists TBSV p33 replication protein insertion to host membrane.	[3,7,35]
TBSV	Rsp5	a member of the Nedd4 family of E3 ubiquitin ligases	Interacts p33 and p92 replicase protein via WW domain; decreases p92 expression while not p33; inhibit virus replication	[71]
BMV	Pus4	Pseudouridine synthase;	increases the minus-strand RNA synthesis by 30%, and decreases viral positive-strand RNA synthesis; helps viral systemic movement in plant.	[29]
	App1p	Protein of unknown function, interacts with Rvs161p and Rvs167p	inhibits the viral RNA synthesis and viral systemic movement	[29]
	Qri1p	UDP-N-acetylglucosamine pyrophosphorylase	inhibits the viral RNA synthesis	[29]
TMV	NbCRT2, NbCRT3	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins	Silencing leads to partial loss of N immune receptor mediated defense to TMV; Induces IRK expression.	[30]
	NbERp57, NbP5	Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen	Silencing leads to partial loss of N immune receptor mediated defense to TMV	[30]
	RPN7	26S proteasome subunit	TMV Induced overexpression of RPN7 leads to the programmed cell death, and causes symptom of TMV.	[48]
BaMV	PNbMTS1	putative methyltransferase	inhibits BaMV coat protein accumulation; silencing of PNbMTS1 stimulates viral RNA accumulation suggesting its antiviral function	[48,74]
ClCuMV-βC1	SIUBC3	ubiquitin-conjugating enzyme	interacts with viral βC1 protein and causes βC1 specific symptom	[82]
PVX	TIP1	homologues of tobacco ankyrin repeat-containing protein	Interacts with PVX p12 movement protein and regulates cell-to-cell movement	[14]