Table 4.
Univariate and multivariate analysis of risk factors related to tumor recurrence
| Risk factors |
Univariate analysis |
Multivariate analysis |
|||
| 3-yr recurrence-free survival rate | HR (95%CI) | Log rank P value | Exp(b) (95%CI) | P value | |
| Tumor grading G3-G4 (vs G1-G2) | 66.7% vs 74.2% | 1.76 (0.289-13.149) | 0.4934 | ||
| Presence of microvascular invasion (vs absence) | 60.0% vs 80.7% | 2.74 (0.451-39.277) | 0.2071 | ||
| Multiple nodules at pathology (vs single) | 69.1% vs 85.7% | 2.15 (0.460-9.070) | 0.3478 | ||
| Repeated TACE (vs single) | 74.1% vs 80.0% | 1.08 (0.244-4.821) | 0.9148 | ||
| Necrosis on CTA ≤ 50% (vs > 50%) | 59.3% vs 100.0% | NA1 | 0.0098 | NA1 | NA1 |
| MC unfulfilled at pathology (vs fulfilled) | 21.4% vs 92.0% | 13.84 (10.121-636.416) | < 0.0001 | 11.6 (1.932-69.646) | 0.0077 |
| Absence of DEB-TACE (vs presence) | 61.5% vs 87.4% | 4.47 (1.005-22.188) | 0.0493 | 15.45 (1.457-163.766) | 0.0237 |
| α-fetoprotein > 70 ng/mL (vs ≤ 70 ng/mL) | 33.3% vs 90.9% | 10.31 (4.749-370.242) | 0.0008 | 15.31 (1.766-132.614) | 0.0137 |
1
Heart rate calculation and the inclusion of the covariate in the multivariate analysis was not applicable due to the lack of hepatocellular carcinoma recurrence events in necrosis on the cumulative tumor area (CTA) > 50% group. TACE: Transcatheter arterial chemoembolization; DEB: Doxorubicin-eluting bead; MC: Milan Criteria; NA: Not available.