Table 1.
Descriptive Characteristics of the AA Studies
| Study | Total Subjects | Age in Years (Mean ± SD) | No. of Males (%) | BMI (Mean ± SD) | No. with HTN (%) | SBP in mmHg (Mean ± SD) | DBP in mmHg (Mean ± SD) | Hypertensive Medication (%) |
|---|---|---|---|---|---|---|---|---|
| BioVu | 942 | 44.3 ± 16.5 | 269 (28.6) | 32.2 ± 10.0 | 673 (67.1) | 131.4 ± 21.1 | 79.3 ± 12.6 | 57.3 |
| ARIC | 2,511 | 53.3 ± 5.8 | 1,045 (36.9) | 29.7 ± 6.0 | 1,612 (58.7) | 128.3 ± 20.8 | 79.7 ± 12.1 | 44.0 |
| CARDIA | 833 | 24.4 ± 3.8 | 366 (38.6) | 25.4 ± 6.1 | 210 (25.2) | 116.9 ± 16.4 | 76.9 ± 12.1 | 13.0 |
| CFS | 489 | 45.7 ± 16.2 | 213 (40.9) | 34.3 ± 9.7 | 209 (44.6) | 128.2 ± 16.0 | 76.5 ± 10.7 | 38.9 |
| JHS | 2,017 | 50.0 ± 12.2 | 213 (39.3) | 32.3 ± 7.8 | 1,193 (56.5) | 124.9 ± 18.0 | 80.0 ± 10.6 | 46.3 |
| MESA | 1,623 | 62.2 ± 10.1 | 745 (45.3) | 30.2 ± 5.9 | 1,019 (62.0) | 131.4 ± 21.7 | 74.5 ± 10.2 | 50.5 |
| CHS | 815 | 72.7 ± 5.7 | 305 (37.4) | 28.5 ± 5.5 | 598 (73.4) | 148.1 ± 23.9 | 78.3 ± 11.6 | 62.7 |
| GeneSTAR | 1,132 | 46.5 ± 12.3 | 432 (38.2) | 32.0 ± 7.8 | 613 (54.2) | 127.7 ± 19.7 | 80.7 ± 11.4 | 37.9 |
| GENOA | 996 | 56.4 ± 11.1 | 295 (29.6) | 31.1 ± 6.8 | 688 (69.1) | 135.6 ± 22.5 | 78.3 ± 12.3 | 56.9 |
| HANDLS | 950 | 48.5 ± 9.0 | 424 (44.6) | 29.9 ± 8.0 | 437 (46.0) | 126.3 ± 19.8 | 75.4 ± 12.1 | 35.5 |
| Health ABC | 1,139 | 73.4 ± 2.9 | 488 (42.8) | 28.6 ± 5.4 | 871 (76.8) | 138.7 ± 21.4 | 72.5 ± 11.3 | 62.7 |
| HyperGEN | 1,252 | 45.2 ± 13.3 | 407 (32.5) | 32.5 ± 7.8 | 780 (54.2) | 134.4 ± 23.5 | 76.5 ± 12.0 | 37.7 |
| Maywood-Loyola | 743 | 42.3 ± 7.8 | 467 (62.9) | 26.7 ± 7.7 | 158 (21.3) | 120.6 ± 19.9 | 77.0 ± 13.4 | 0.7 |
| Nigeria-Loyola | 1,188 | 47.8 ± 15.5 | 510 (42.9) | 23.3 ± 5.1 | 443 (37.3) | 127.9 ± 26.4 | 77.8 ± 14.9 | 3.8 |
| Mt. Sinai Study | 873 | 59.3 ± 12.5 | 364 (41.7) | 30.7 ± 7.8 | 803 (92.0) | 134.2 ± 19.6 | 76.7 ± 10.5 | 88.3 |
| WHI-SHARe | 8,094 | 61.6 ± 7.0 | 0 (0.0) | 31.0 ± 6.4 | 4,780 (59.0) | 132.2 ± 17.9 | 78.1 ± 9.4 | 46.2 |
| HUFS | 1,017 | 48.4 ± 13.2 | 419 (41.2) | 30.5 ± 8.3 | 509 (50.0) | 131.3 ± 21.9 | 81.4 ± 13.3 | 13.3 |
| BHS | 368 | 37.6 ± 4.9 | 142 (38.6) | 31.4 ± 8.7 | 105 (28.5) | 125.8 ± 19.5 | 83.7 ± 13.0 | 16.2 |
| SIGNET | 2,396 | 63. 5 ± 8.6 | 870 (36.3) | 31.5 ± 6.9 | 585 (24.4) | 137.3 ± 18.8 | 81.4 ± 10.8 | 71.4 |
| AA Replication Cohorts | ||||||||
| JUPITER | 1,688 | 66.4 ± 8.1 | 850 (50.3) | 28.2 ± 7.3 | 1,067 (63.7) | 140.7 ± 17.7 | 84.3 ± 9.4 | 53.3 |
| Ghana | 3,420 | 43.0 ± 13.6 | 1,452 (42.5) | 24.7 ± 5.0 | 784 (22.9) | 127.3 ± 19.9 | 76.8 ± 12.0 | 0.0 |
| FBPP-AXIOM | 872 | 48.9 ± 13.1 | 372 (42.6) | 31.1 ± 7.0 | 604 (69.2) | 128.8 ± 21.6 | 74.6 ± 11.9 | 65.4 |
| HRS | 1,337 | 66.5 ± 10.2 | 483 (36.1) | 30.5 ± 6.5 | 1,073 (80.3) | 137.3 ± 23.2 | 82.2 ± 13.0 | 66.9 |
| Mt. Sinai IPM Biobank Program | 3,057 | 50.2 ± 14.7 | 1,018 (33.3) | 30.7 ± 8.2 | 1,999 (65.4) | 136.0 ± 23.0 | 80.0 ± 21.0 | 65.2 |
| The Seychelles TANDEM | 483 | 48.1 ± 13.6 | 203 (42.0) | 27.8 ± 5.4 | 310 (64.2) | 135.6 ± 22.6 | 84.5 ± 12.5 | 44.3 |
| The Seychelles Heart Study III | 906 | 44.9 ± 11.2 | 401 (44.3) | 27.2 ± 5.7 | 396 (43.7) | 129.5 ± 20.0 | 84.2 ± 12.3 | 27.9 |
Characteristics of studies contributing to the COGENT BP meta-analyses. Abbreviations are as follows: BMI, body mass index; BioVU, DNA databank of Vanderbilt University; ARIC, Atherosclerosis Risk in Communities; CARDIA, Coronary Artery Risk Development in Young Adults; CFS, Cleveland Family Study; JHS, Jackson Heart Study; MESA, Multi-Ethnic Study of Atherosclerosis; CHS, Cardiovascular Health Study; GeneSTAR, Genetic Study of Atherosclerosis Risk; GENOA, Genetic Epidemiology Network of Arteriopathy; HANDLS, The Healthy Aging in Neighborhoods of Diversity across the Life Span study; Health ABC, Health, Aging, and Body Composition study; HyperGEN, Hypertension Genetic Epidemiology Network; Maywood-Loyola, Maywood study at Loyola University Medical Center; Nigeria-Loyola, Nigeria study at Loyola University Medical Center; Mt. Sinai Study, Mount Sinai, New York City, USA, study; WHI-SHARe, Women’s Health Initiative SNP Health Association Resource; HUFS, Howard University Family Study; BHS, Bogalusa Heart Study; SIGNET, Sea Islands Genetic Network; JUPITER, Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin; Ghana, Ghana study at Vanderbilt University; FBPP-AXIOM, Family Blood Pressure Program-AXIOM; HRS, Health and Retirement Study; and Mt. Sinai IPM Biobank, Mount Sinai Institute for Personalized Medicine Biobank Program.