Table 2.
Meta-analyses of COGENT Discovery AA Samples and Replication in EA, East Asian, and Additional AA Data Sets
| Chr | SNP | Gene | Effect Allele/Other Allele |
Discovery COGENT |
Transethnic Replication |
Transethnic Meta-analysis pb,c | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect Allele Frequency | Trait | Beta (SE) | COGENT pa | EA ICBP pa | AA pa | East Asian pa | |||||
| 6 | rs13209747 | RSPO3 | T/C | 0.19 | SBP | 0.85 (0.21) | 5.9 × 10−5 | 5.4 × 10−4 | 5.0 × 10−4 | 2.6 × 10−3 | 2.6 × 10−10 |
| DBP | 0.56 (0.12) | 8.8 × 10−6 | 1.5 × 10−3 | 2.2 × 10−2 | 1.2 × 10−4 | 2.4 × 10−11 | |||||
| 6 | rs17080102 | PLEKHG1 | C/G | 0.1 | SBP | −1.02 (0.25) | 3.4 × 10−5 | 9.2 × 10−4 | 2.3 × 10−1 | 3.4 × 10−2 | 4.8 × 10−8 |
| DBP | −0.74 (0.15) | 5.4 × 10−7 | 1.5 × 10−4 | 4.1 × 10−1 | 8.5 × 10−4 | 1.9 × 10−11 | |||||
| 6 | rs6924906 | C6orf37 (FAM46A) | T/C | 0.71 | SBP | −0.41 (0.17) | 1.7 × 10−2 | 5.6 × 10−4 | 4.7 × 10−1 | 2.0 × 10−3 | 6.2 × 10−5 |
| DBP | −0.51 (0.10) | 5.6 × 10−7 | 4.9 × 10−2 | 9.8 × 10−1 | 8.8 × 10−3 | 5.5 × 10−7 | |||||
| 7 | rs17428471 | EVX1-HOXA | T/G | 0.14 | SBP | 1.20 (0.24) | 4.0 × 10−7 | 8.0 × 10−6 | 1.4 × 10−4 | 3.4 × 10−1 | 2.1 × 10−12 |
| DBP | 0.61 (0.14) | 1.2 × 10−5 | 2.8 × 10−5 | 1.1 × 10−2 | 4.4 × 10−1 | 1.6 × 10−9 | |||||
| 3 | rs1717027 | ULK4d | T/C | 0.64 | SBP | 0.18 (0.16) | 2.6 × 10−1 | 5.0 × 10−1 | 6.0 × 10−1 | 5.6 × 10−1 | 3.0 × 10−1 |
| DBP | 0.49 (0.10) | 5.1 × 10−7 | 2.5 × 10−7 | 2.2 × 10−2 | 1.5 × 10−1 | 4.6 × 10−13 | |||||
| 11 | rs1401454 | SOX6d | T/C | 0.46 | SBP | 0.55 (0.16) | 5.7 × 10−4 | 2.2 × 10−4 | 9.7 × 10−4 | 6.7 × 10−1 | 9.5 × 10−7 |
| DBP | 0.45 (0.10) | 2.1 × 10−6 | 3.1 × 10−5 | 5.0 × 10−3 | 5.5 × 10−1 | 5.1 × 10−10 | |||||
| 11 | rs11041530 | CYB5R2 | C/G | 0.11 | SBP | −1.35 (0.25) | 4.0 × 10−8 | 0.029 | 8.0 × 10−1 | 9.3 × 10−1 | 5.6 × 10−6 |
| DBP | −0.54 (0.15) | 2.6 × 10−4 | 0.119 | 6.5 × 10−1 | 6.6 × 10−1 | 7.6 × 10−4 | |||||
Boldface indicates genome-wide significance after correction for the number of SNPs and traits. The following abbreviation is used: Chr, chromosome.
a
Significant thresholds: COGENT discovery, p < 5.0 × 10−8; replication in ICBP, p = 5.8 × 10−4; further replication in AA and East Asians, p = 0.0037.
b
Final significant variants were defined with the significance threshold of p < 1.67 × 10−8 after adjustment for the three traits.
c
p values were combined for the analysis of the ICBP meta-analysis of EA samples. The replication sample size and power for each SNP in the AA studies are presented in Table S5.