Table III.
Univariate Analysis for Progression Free Survival and Overall Survival
| PFS variable | HR | p-value |
|---|---|---|
| Number of prev therapy >1 vs 1 |
1.60 | 0.02 |
| Pre-SCT response Others vs. CR+VGPR |
1.67 | 0.018 |
| Post-SCT response Others vs. CR+VGPR |
2.79 | <0.001 |
| Pre-SCT response Others vs. CR |
2.49 | 0.015 |
| Post-SCT response Others vs. CR |
3.63 | <0.001 |
| Durie salmon 3 vs.1 or 2 |
1.80 | 0.033 |
| Complex Karyotype No vs. yes |
0.63 | 0.042 |
| Del 13 Karyotype No. vs. yes |
0.56 | 0.035 |
| High risk FISH/Karyotype No vs. yes |
0.65 | 0.041 |
| ISS 1 vs. 2/3 |
1 vs. 2: 0.89 1vs. 3: 0.49 2 vs. 3: 0.56 |
0.038 |
| OS Variable | ||
| Pre-SCT response Others vs. CR |
1.74 | 0.35 |
| Post-SCT response Others vs. CR |
3.10 | 0.0043 |
| Del 13 Karyotype No vs. yes |
0.44 | 0.045 |
| HD No vs. yes |
0.36 | 0.018 |
HR stands for hazard ratio; prev previous; SCT stem cell transplant; CR complete response; VGPR very good partial response; PR partial response; SD stable disease; NRM non relapse mortality; OS overall survival; PFS progression free survival; FISH florescent in-situ hybridization; ISS international scoring system; HD hemodialysis.