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. Author manuscript; available in PMC: 2014 Jun 21.
Published in final edited form as: Circ Res. 2013 Apr 26;113(1):62–71. doi: 10.1161/CIRCRESAHA.113.300975

Figure 6. Regulated microRNA-mRNA interactomes in miR-378 and miR-499 hearts.

Figure 6

A. Parent gene and encoded microRNA levels are regulated similarly by microRNAs. Fold-changes of parent gene (white bars) and encoded microRNA (black bars) are shown for miR-378 and miR-499 regulated microRNAs. * indicates significant regulation of parent mRNA at genome-wide significance for multiple comparisons. B. and C. Heat maps of microRNA and mRNA regulation in miR-378 (B) and miR-499 (C) transgenic hearts and secondary consequences of regulated microRNAs on cardiac transcript levels. Left panels: mRNAs downregulated in transgenic hearts by the primary microRNA. Center panels: microRNAs secondarily upregulated in transgenic hearts. Right panels: mRNAs predicted by FastamiRs to be targeted by each secondarily regulated microRNA (details in Online Table III). Colors represent abundances of microRNAs and mRNAs.