Skip to main content
. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Tetrahedron. 2013 Apr 6;69(27-28):5622–5633. doi: 10.1016/j.tet.2013.04.003

Table 1.

Catalyst screen.

graphic file with name nihms-474474-t0002.jpg

entry BINOL derivative yield (%)a d.r.b ee (%)c
1 H (7) 88 10:1 90
2 6,6'-(OMe)2 (22) 63 6:1 82
3 6,6'-Br2 (23) 65 8:1 86
4 3,3'-Me2 (24) 63 8:1 90
5 3,3'-Br2 (17) 63 16:1 90
6 3,3'-Cl2 (25) 73 14:1 91
a

Isolated yield of exo:endo mixture.

b

Determined by 1H NMR analysis of crude reaction mixture.

c

Determined by HPLC using chiral stationary phase.