Table 1.
Characteristics of the 29 studies included in the meta-analysis.
| Author (s), year | Patients included | Men (%) | Age (years) | Albuminuria | Interventions | Treatment duration | Jadad score | |
|---|---|---|---|---|---|---|---|---|
| Experimental | Control | |||||||
| Ma et al., 2011 [12] | 409 | 45 | 56.6 | Microalb Macroalb |
Arctiin granule (TID) | Placebo (TID) | 8 weeks | 5 |
| Chen, 2010 [13] | 60 | 45 | 60.5 | Microalb Macroalb |
Anshen yin (TID) | Losartan (50 mg/d, QD) | 12 weeks | 2 |
| Xu, 2005 [14] | 64 | 62.5 | 56.2 | Microalb | Baoshen tang (TID) | Benazepril (5–10 mg/d, QD) | 12 weeks | 2 |
| Luo, 2008 [15] | 72 | 54.2 | 56.8 | Microalb | Bushen Huoxue decoction (BID) | Benazepril (10 mg/d, QD) | 12 weeks | 3 |
| Huang and Xu, 2008 [16] | 68 | 54.4 | 58.0 | Microalb | Tangluo Tongshui decoction (BID) | Losartan (50 mg/d, QD) | 8 weeks | 2 |
| Ge et al., 2010 [17] | 55 | 56.9 | 51.5 | Macroalb | Tripterygium glycosides (120 mg/d, TID) | Valsartan (160 mg/d, QD) | 24 weeks | 3 |
| Xue and Bai, 2008 [18] | 60 | 55.0 | NA | Microalb | Liuwei Dihuang tang (BID) | Losartan (100 mg/d, QD) | 12 weeks | 2 |
| Zhang, 2012 [19] | 70 | 54.3 | 62.4 | Microalb | Pishen Shuangbu tang (BID) | Benazepril (10 mg/d, QD) | 4 weeks | 2 |
| Huang, 2011 [20] | 70 | 52.9 | 56.0 | Microalb | Shen an decoction (BID) | Captopril (37.5 mg/d, TID) | 8 weeks | 2 |
| Zhang et al., 2011 [21] | 227 | NA | NA | Microalb Macroalb |
Tangshen Kang capsule (TID) | Enalapril (10 mg/d, BID) | 8 weeks | 3 |
| Huang, 2012 [22] | 80 | 61.3 | 53.1 | Macroalb | Wenshen Jianpi Huoxue tang (BID) | Benazepril (10 mg/d, QD) | 8 weeks | 2 |
| Dong et al., 2007 [23] | 68 | 57.4 | 55.0 | Microalb | Yiqi Huoxue tang (BID) | Valsartan (80 mg/d, QD) | 8 weeks | 2 |
| Zhou et al., 2009 [24] | 109 | 38.5 | 54.8 | Microalb | Tangshen decoction (BID) | Losartan (50 mg/d, QD) | 12 weeks | 3 |
| Wang et al., 2012 [25] | 75 | 51.3 | 57.2 | Microalb | Yiqi Yangyin Xiaozheng Tongluo decoction (BID) | Irbesartan (150 mg/d, QD) | 48 weeks | 3 |
| Zhong et al., 2012 [26] | 100 | 53.0 | 48.0 | Macroalb | Ziyin Zhuyang Digui tang (BID) | Benazepril (10 mg/d, QD) | 12 weeks | 2 |
| Chen and Wan, 2011 [27] | 62 | 48.4 | 61.6 | Microalb | Qishen Yiqi drop pill (TID) Enalapril (10 mg/d, QD) |
Enalapril (10 mg/d, QD) | 8 weeks | 2 |
| Wei et al., 2010 [28] | 60 | 55.0 | NA | Microalb | Fufang Danpi decoction (BID) Benazepril (10 mg/d, QD) |
Benazepril (10 mg/d, QD) | 8 weeks | 2 |
| Feng et al., 2005 [29] | 60 | 63.3 | 54.8 | Microalb | Kangshen tang (BID) Benazepril (10 mg/d, QD) |
Benazepril (10 mg/d, QD) | 12 weeks | 2 |
| Zhu et al., 2004 [30] | 42 | 50.0 | 54.8 | Microalb | Pingxiao Gujing tang (BID) Benazepril (10 mg/d, QD) |
Benazepril (10 mg/d, QD) | 8 weeks | 2 |
| Li et al., 2006 [31] | 81 | 49.4 | 50.7 | Microalb | Tangshen ling decoction (BID) Telmisartan (80 mg/d, QD) |
Telmisartan (80 mg/d, QD) | 8 weeks | 2 |
| Pan and Xue, 2009 [32] | 81 | 46.6 | 54.4 | Microalb | Tangshen tang (BID) Valsartan (80 mg/d, QD) |
Valsartan (80 mg/d, QD) | 8 weeks | 3 |
| Gong and Wang, 2004 [33] | 80 | 53.8 | 59.0 | Microalb | Yangyin Yiqi decoction (BID) benazepril (10 mg/d, QD) |
Benazepril (10 mg/d, QD) | 8 weeks | 2 |
| Cai et al., 2012 [34] | 63 | 63.5 | 41.7 | Microalb | Yiqi Yangyin Huazhuo Tongluo decoction (BID) Benazepril (10 mg/d, QD) |
Benazepril (10 mg/d, QD) | 8 weeks | 3 |
| Qu, 2012 [35] | 68 | 55.9 | 62.4 | Microalb | Chunze tang (BID) Benazepril (10 mg/d, QD) |
Benazepril (10 mg/d, QD) | 2 weeks | 2 |
| Li, 2004 [36] | 40 | 45.0 | 51.8 | Microalb | Modified Liuwei Dihuang tang (BID) Enalapril (10 mg/d, QD) |
Enalapril (10 mg/d, QD) | 12 weeks | 2 |
| Wu and Zhang, 2005 [37] | 60 | 43.3 | 59.0 | Microalb | Tangshen kang (BID) Fosinopril (10 mg/d, QD) |
Fosinopril (10 mg/d, QD) | 8 weeks | 2 |
| Chen and Huang, 2006 [38] | 60 | NA | NA | Microalb | Wuchong tang (BID) Benazepril (10 mg/d, QD) |
Benazepril (10 mg/d, QD) | 8 weeks | 3 |
| Fallahzadeh et al., 2012 [39] | 56 | 46.7 | 56.8 | Macroalb | Silymarin (520 mg/d, TID) ACEI/ARB |
Placebo (TID) ACEI/ARB |
12 weeks | 5 |
| Khajehdehi et al., 2011 [40] | 40 | 55 | 52.8 | Macroalb | Turmeric (1500 mg/d, TID) ACEI/ARB |
Placebo (TID) ACEI/ARB |
8 weeks | 4 |
Microalb: microalbuminuria; Macroalb: Macroalbuminuria; QD: once a day; BID: twice a day; TID: three times a day. NA: not applicable.