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Microsomes from livers of wild-type or liver-specific 11β-HSD1 knockout (LKO) mice were incubated for 60 min with 7-oxoLCA (1 µM), hexose-6-phosphate (1 mM G6P) or NAPDH (1 mM), and 11β-HSD1 inhibitor T0504 (5 µM) as indicated. 7-oxoLCA is presented by white bars; CDCA and UDCA are presented by black and hatched bars, respectively. Data (n = 3) represent mean ± SD. Reactions were terminated with acetonitrile, and then extracted and measured by LC-MS/MS.
