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The predicted binding orientations of cortisone in (A) human and (B) guinea-pig and 7-oxoLCA in (C) human and (D) guinea-pig in the 11β-HSD binding sites. The catalytic triad Ser-Tyr-Lys is highlighted in ball-and-stick style, and the cofactor NADPH, in bold sticks. The ligands are represented in gray.
