TABLE 2.
Impact of bile acids on the interconversion of glucocorticoids by 11β-HSD1 from six species
| 11β-HSD1 Species | Reductase Activity IC50 (µM) | Dehydrogenase Activity IC50 (µM) | |
| Human | 7-oxoLCA | 1.1 ± 0.3 | 2.8 ± 0.8 |
| UDCA | 6.9 ± 1.2 | 2.3 ± 1.0 | |
| CDCA | 4.1 ± 0.6 | 0.3 ± 0.1 | |
| Rat | 7-oxoLCA | 2.4 ± 0.9 | 11 ± 3 |
| UDCA | 13 ± 3 | 7 ± 3 | |
| CDCA | 0.7 ± 0.1 | 0.7 ± 0.3 | |
| Mouse | 7-oxoLCA | 3.5 ± 0.6 | 12 ± 3 |
| UDCA | 32 ± 9 | 18 ± 3 | |
| CDCA | 2.3 ± 0.4 | 1.6 ± 0.1 | |
| Hamster | 7-oxoLCA | 2.3 ± 0.9 | 29 ± 7 |
| UDCA | 21 ± 8 | 13 ± 4 | |
| CDCA | 44 ± 14 | 5 ± 1 | |
| Canine | 7-oxoLCA | 0.9 ± 0.2 | 16 ± 3 |
| UDCA | 26 ± 5 | 18 ± 3 | |
| CDCA | 1 ± 0.1 | 0.9 ± 0.2 | |
| Guinea pig | 7-oxoLCA | 15 ± 4 | 11 ± 20 |
| UDCA | 55 ± 15 | 39 ± 18 | |
| CDCA | 22 ± 4 | 12 ± 2 |
The results are mean ± SD (n = 3).