TABLE 4.

Circulating and intrahepatic concentrations of 7-oxoLCA and its conjugates in mouse models of 11β-HSD1 deficiency

	Circulation (nM)			Intrahepatic (fmol/mg)
	WT	LKO	KO	WT	LKO	KO
7-oxoLCA	15 ± 11	91 ± 152**	360 ± 529***	15 ± 10	33 ± 34	27 ± 21
7-oxoLC-Tau	22 ± 19	875 ± 1210*	407 ± 392***	200 ± 188	1458 ± 1705***	874 ± 945***
7-oxoLC-Gly	14 ± 14	4 ± 6	18 ± 16	8 ± 8	10 ± 9	2 ± 1

The results are expressed in nM as mean ± SD. Wild-type (WT) (n = 24), liver-specific 11β-HSD1-deficient mice (LKO) (n = 16) and global 11β-HSD1-deficient mice (KO) (n = 8). Data represent mean ± SD. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.