TABLE 5.
Linear regression of lipid classes and subclasses with age and BMI
| Lipid Class or Subclassa | Age (years) | BMI (kg/m2) | ||
| β-Coefficient (95% CI)b | Pc | β-Coefficient (95% CI)d | Pc | |
| dhCer | 0.72 (−0.30–1.74) | 2.01E-01 | 2.01 (1.56–2.47) | 2.22E-16 |
| Cer | 3.55 (2.50–4.60)e | 1.16E-09 | 0.14 (−0.38–0.65) | 6.66E-01 |
| MHC | 1.81 (0.76–2.85) | 2.31E-03 | −0.70 (−1.19–0.20) | 9.46E-03 |
| DHC | 1.05 (−0.03–2.12) | 7.73E-02 | −0.79 (−1.30–0.29) | 3.92E-03 |
| THC | 3.08 (2.08–4.08) | 2.73E-08 | −1.27 (−1.75–0.80) | 6.82E-07 |
| GM | 2.89 (1.83–3.95) | 5.87E-07 | −1.59 (−2.09–1.09) | 3.18E-09 |
| SM | 3.33 (2.22–4.44) | 4.55E-08 | 0.95 (0.41–1.49) | 1.30E-03 |
| PC | 1.53 (0.40–2.67) | 1.44E-02 | 0.93 (0.39–1.46) | 1.47E-03 |
| PC(O) | −1.46 (−2.55–0.36) | 1.65E-02 | −0.18 (−0.70–0.34) | 5.79E-01 |
| PC(P) | −0.36 (−1.38–0.65) | 5.05E-01 | −0.57 (−1.05–0.09) | 2.94E-02 |
| LPC | 0.73 (−0.30–1.77) | 2.01E-01 | −1.44 (−1.91–0.96) | 1.57E-08 |
| LPC(O) | 1.25 (0.17–2.33) | 3.54E-02 | −2.04 (−2.53–1.56) | 3.51E-15 |
| PE | 1.59 (0.48–2.70) | 1.18E-02 | 0.61 (0.08–1.14) | 3.40E-02 |
| PE(O) | 0.43 (−0.59–1.44) | 4.48E-01 | 0.07 (−0.41–0.55) | 7.90E-01 |
| PE(P) | 0.20 (−0.85–1.25) | 7.12E-01 | 0.45 (−0.05–0.94) | 9.54E-02 |
| LPE | 1.60 (0.61–2.60) | 4.74E-03 | −1.09 (−1.56–0.63) | 1.45E-05 |
| PI | 2.36 (1.26–3.46) | 1.09E-04 | 0.56 (0.04–1.09) | 4.96E-02 |
| PS | −0.39 (−1.26–0.49) | 4.48E-01 | −0.09 (−0.51–0.33) | 7.06E-01 |
| PG | 1.23 (0.23–2.23) | 2.70E-02 | 0.79 (0.32–1.26) | 1.95E-03 |
| CE | 1.63 (0.59–2.68) | 5.86E-03 | 1.53 (1.05–2.01) | 3.59E-09 |
| COH | 2.79 (1.76–3.82) | 5.87E-07 | 0.52 (0.02–1.01) | 5.38E-02 |
| DG | 1.04 (0.09–1.98) | 4.56E-02 | 0.99 (0.55–1.43) | 2.97E-05 |
| TG | 1.34 (0.35–2.33) | 1.44E-02 | 1.50 (1.04–1.95) | 1.30E-09 |
a
Sum of the individual species within that class or subclass.
b
Adjusted for sex, BMI, SBP, 2 h post load glucose, and smoking status.
c
Benjamini and Hochberg corrected. Bold type indicates P < 0.05.
d
Adjusted for sex, age, SBP, 2 h post load glucose, and smoking status.
e
An interquartile range increase in Cer levels is associated with a mean increase in age of 3.55 years.