Name | Definition | Method of estimation | Terminology |
---|---|---|---|
Phenotypic correlation | Correlation between two phenotypes in the same subject. In classical twin studies this is termed a within-twin cross-trait correlation | The ratio of the deviation from the population mean of the group mean in the secondary variable of the probands to the deviation from the population mean of the group mean in the primary variable of the probandsa | Bivariate group within-subject correlation |
Shared familiality or cross-sibling cross-trait correlation | Correlation between siblings for two phenotypes. It is analogous to a dizygotic cross-twin cross-trait correlation in a twin study | The ratio of the deviation from the population mean of the group mean in the secondary variable of the siblings to the deviation from the population mean of the group mean in the primary variable in the probandsa | Bivariate sibling correlation |
Percentage of phenotypic correlation due to shared familial effects | (2×bivariate familial correlation)/phenotypic correlation. This assumes that familial correlation is accounted for entirely by additive genesb |
The variances of the selection variable and the secondary variable have been equated.
The percentage of phenotypic correlation due to additive genetic effects only holds in instances where the variance–covariance structure of the primary phenotype is known unequivocally.