Figure 5.
Activity of AT-101 in (A) SK-N-AS and (B) NLF. AT-101 concentration symbol legend: ○ = 0 µM (media alone); ▪ = 0.2 µM; * = 2 µM; ▲ = 5 µM; ●= 10 µM. (C and D): 24 hours of Mcl1 knockdown augments the early response to AT-101 at intermediate concentrations. ▲ = 5 µM AT-101; ◆ = 5 µM AT-101 with 5 nM siMCL1; ◊ = 5 nM siMCL1 alone; ○ = media. Curves are representative of at least 2 independent experiments.