Table 4.

Mortality and Cardiovascular Morbidity in the Stage A/B Heart Failure Subgroup (n = 1,228) During 10 Years of Follow-Up According to Baseline NT-proBNP

Outcome (No. of Events)	HR (95% CI) per 1 SD Increase in Log Variable	p Value	HR (95% CI) for Values Above 80th Percentile	p Value
Death (170)
Unadjusted model	2.65 (2.23–3.14)	<0.001	1.70 (1.25–2.33)	<0.001
Age-, sex-, BMI-adjusted	1.76 (1.45–2.13)	<0.001	2.01 (1.47–2.75)	<0.001
Multivariable model 1*	1.75 (1.43–2.14)	<0.001	2.02 (1.45–2.81)	<0.001
Multivariable model 2†	1.55 (1.23–1.96)	<0.001	1.60 (1.10–2.32)	0.014
Heart failure (156)
Unadjusted model	1.75 (1.52–2.01)	<0.001	1.60 (1.22–2.09)	<0.001
Age-, sex-, BMI-adjusted	1.38 (1.18–1.62)	<0.001	1.77 (1.35–2.32)	<0.001
Multivariable model 1*	1.28 (1.09–1.52)	0.004	1.56 (1.18–2.06)	0.002
Multivariable model 2†	1.26 (1.05–1.51)	0.015	1.51 (1.12–2.03)	0.007
Myocardial infarction (133)
Unadjusted model	2.77 (2.29–3.35)	<0.001	2.49 (1.82–3.41)	<0.001
Age-, sex-, BMI-adjusted	2.30 (1.87–2.84)	<0.001	3.00 (2.18–4.12)	<0.001
Multivariable model 1*	2.16 (1.72–2.70)	<0.001	2.63 (1.87–3.68)	<0.001
Multivariable model 2†	1.63 (1.27–2.09)	<0.001	1.74 (1.20–2.53)	0.004
Cerebrovascular accident (236)
Unadjusted model	1.68 (1.39–2.02)	<0.001	2.22 (1.58–3.14)	<0.001
Age-, sex-, BMI-adjusted	1.61 (1.31–1.99)	<0.001	2.49 (1.76–3.52)	<0.001
Multivariable model 1*	1.36 (1.07–1.71)	0.011	2.03 (1.41–2.91)	<0.001
Multivariable model 2†	1.33 (1.03–1.73)	0.029	2.05 (1.39–3.03)	<0.001

^*Adjustment for age, sex, body mass index (BMI), total cholesterol, serum creatinine, presence of diabetes mellitus, hypertension, and coronary artery disease.

^†Adjustment for variables in model 1 in addition to presence of ejection fraction <50%, diastolic dysfunction, valvular dysfunction, left ventricular hypertrophy, left atrial enlargement, and wall motion abnormalities.

Abbreviations as in Table 3.