Table 4.
Characteristics of regenerative materials used in the reviewed clinical and experimental studies.
| Regenerative material | Product name | Action | Clinical studies | Experimental studies |
|---|---|---|---|---|
| Membranes | ||||
| ePTFE-membrane (expanded Polytetra-fluoroethylene), synthetic and non-resorbable | Gore-Tex® | Barrier membrane to provide a protected space | Pecora et al. (1995) and Tobon et al. 2002 | Yoshikawa et al. (2002), Dahlin et al. (1990) and Baek and Kim (2001) |
| PLA-membrane (polylactide), synthetic and resorbable | Guidor® | Membrane to provide a temporary protected space | Garrett et al. (2002) | Maguire et al. (1998), Baek and Kim (2001) and Douthitt et al. (2001) |
| Collagen-membrane (collagen type I and III), porcine-derived and resorbable | Bio-Gide® | Bilayer membrane to provide a temporary protected space | Taschieri et al. (2007, 2008), Dietrich et al. (2003) and Britain et al. 2005 | |
| Lyophilized decalcified cortical bone membrane, bovine-derived and resorbable | Gen-derm® | Membrane to provide a temporary protected space | Bernabé et al. (2010) | |
| Polyglactin 910-membrane (co-polymer of 90% glycolide and 10% l-lactide), synthetic and resorbable | Vicryl® | Membrane to provide a temporary protected space | Marin et al. (2006) | Baek and Kim (2001) |
| Collagen tape (collagen type I), bovine-derived and resorbable | CollaTape® | Tape to provide a temporary protected space | Kim et al. (2008) | |
| Bone fillers | ||||
| IBBM particulate (inorganic bovine bone mineral), bovine-derived and non-resorbable | Bio-Oss® | Osteoconductive filler | Stassen et al. (1994), Taschieri et al. (2007, 2008), Dietrich et al. (2003) and Britain et al. (2005) | |
| Lyophilized bone matrix, bovine-derived | Gen-ox® | Osteoconductive and osteoinductive filler | Bernabé et al. (2010) | |
| Synthetic non-ceramic hydroxyapatite, resorbable | Osteogen® | Osteoconductive filler | Tobon et al. (2002) | |
| Synthetic glass particles (calcium phospho silicate) resorbable | PerioGlas® | Osteostimulative and osteoconductive filler | Pantchev et al. (2009) | |
| CS particulate (calcium sulfate), synthetic and resorbable | Surgiplaster®∗, Capset®∗∗ | Osteoconductive filler | ∗Pecora et al. (2001) | ∗Murashima et al. (2002), ⁎Yoshikawa et al. (2002) and ⁎⁎Apaydin and Torabinejad (2004) |
| Growth factors | ||||
| hOP-1 (human osteogenic protein) (carrier: collagen matrix) | – | hOP-1, also known as BMP-7, belongs to the TGF-beta superfamily (transforming growth factors) and is osteostimulative | Maguire et al. (1998) | |
| rhBMP-2 (recombinant human bone morphogenetic protein) (carrier: collagen matrix) | – | BMP-2 belongs to the TGF-beta superfamily (transforming growth factors) and is osteostimulative | Bergenholtz et al. (2006) | |