Table 1.
Clinical/Pathologic Characteristics of 89 Patients with Metastatic Papillary Thyroid Carcinoma
| Primary (n=60): number (%) | Recurrent (n=29): number (%) | p-Value | |
|---|---|---|---|
| Age | |||
| Median (range) | 44 (20–85) | 42 (22–82) | 0.35 |
| Sex | |||
| Female | 37 (61.7%) | 22 (75.9%) | 0.17 |
| Histologic variant | |||
| Classic papillary carcinoma | 45 (75%) | 21 (72.4%) | 0.74 |
| Follicular variant | 6 (10%) | 2 (6.9%) | |
| Tall cell variant | 9 (15%) | 6 (20.7%) | |
| Overall stagea | |||
| Stage I | 33 (55%) | 17 (68%) | .007 |
| Stage II | 0 (0%) | 2 (8%) | |
| Stage III | 1 (1.7%) | 2 (8%) | |
| Stage IV | 26 (43.3%) | 4 (16%) | |
| T-classificationa | |||
| T1 | 17 (28.3%) | 2 (6.9%) | 0.072 |
| T2 | 8 (13.3%) | 8 (27.6%) | |
| T3 | 27 (45%) | 14 (48.3%) | |
| T4 | 8 (13.3%) | 5 (17.2%) | |
| Nodal metastases | |||
| Lateral compartment | 44 (73%) | 25 (86%) | 0.28 |
| Central compartment | 56 (93%) | 22 (76%) | 0.04 |
| M-stagea | |||
| Distant disease present | 0 (%) | 0 (0%) | 1 |
| ATA staging systemb | |||
| High risk | 8 (13.3%) | 5 (17.2%) | 0.75 |
| Intermediate risk | 52 (86.7%) | 24 (82.8%) | |
| Extranodal extensionc | |||
| ENE present | 16 (26.7%) | 13 (45%) | 0.09 |
| Metastatic lymph nodes | |||
| Lateral compartment | |||
| Median positive (range) | 4 (1–18) | 5 (1–14) | 0.98 |
| Total harvested (range) | 44 (17–80) | 41 (8–78) | |
| Central compartment | |||
| Median positive (range) | 3 (0–20) | 3 (0–12) | 0.24 |
| Total harvested (range) | 9 (2–32) | 3 (0–15) | |
| Radioiodine treatment, median (range) | |||
| Before surgery | NA | 156 mCi (0–452) | |
| After surgery | 150 mCi (93–250) | 115 mCi (0–250) | |
| External beam radiation after surgery | 7 (11.7%) | 3 (10.3%) | 1 |