Table 4.
Association of TSH and Vitamin D Tertiles With Prognostic Features and Thyroid Cancer Stage
| Tertile 1 | Tertile 2 | Tertile 3 | pa | |
|---|---|---|---|---|
| TSH | ||||
| n in tertile (min–max values) | 16 (0.50–1.17) | 17 (1.18–1.50) | 15 (1.60–3.70) | — |
| Tumor size | 1.8±1.3 | 2.4±1.8 | 2.7±1.7 | 0.13 |
| Extrathyroidal extension | 6 (38%) | 9 (53%) | 9 (60%) | 0.21 |
| Multifocality | 9 (56%) | 8 (47%) | 7 (47%) | 0.59 |
| Number of foci | 2.1±1.2 | 2.1±1.5 | 2.4±2.0 | 0.56 |
| Number of positive lymph nodes | 2.0±4.8 | 1.7±3.0 | 4.9±7.1 | 0.13 |
| Distant metastases | 0 (0%) | 0 (0%) | 2 (13%) | —b |
| NTCTCSG Stage 1 | 11 (69%) | 5 (29%) | 6 (40%) | 0.072c |
| NTCTCSG Stage 2 | 2 (12%) | 6 (35%) | 3 (20%) | |
| NTCTCSG Stage 3 | 3 (19%) | 6 (35%) | 4 (27%) | |
| NTCTCSG Stage 4 | 0 (0%) | 0 (0%) | 2 (13%) | |
| Vitamin D | ||||
| n in tertile (min–max values) | 16 (8–19) | 17 (21–30) | 15 (32–50) | — |
| Tumor size | 2.8±2.2 | 1.9±1.1 | 2.3±1.3 | 0.34 |
| Extrathyroidal extension | 9 (56%) | 9 (53%) | 6 (40%) | 0.37 |
| Multifocality | 9 (56%) | 8 (47%) | 7 (47%) | 0.59 |
| Number of foci | 2.3±1.3 | 2.2±1.9 | 2.1±1.6 | 0.84 |
| Number of positive lymph nodes | 0.8±1.6 | 4.2±6.8 | 3.3±5.4 | 0.19 |
| Distant metastases | 2 (13%) | 0 (0%) | 0 (0%) | —b |
| NTCTCSG stage 1 | 7 (44%) | 7 (41%) | 8 (53%) | 0.13c |
| NTCTCSG stage 2 | 2 (13%) | 4 (24%) | 5 (33%) | |
| NTCTCSG stage 3 | 5 (31%) | 6 (35%) | 2 (13%) | |
| NTCTCSG stage 4 | 2 (13%) | 0 (0%) | 0 (0%) | |
Data are mean±SD or n (%).
a
p Value for linear trend.
b
The test is not reliable due to the small event number (n=2 with distant metastases).
c
Exact test.