Table 3.
Enzyme | Renin | ACE | Aminopetidase A | Aminopetidase N |
---|---|---|---|---|
Structure | 340 amino acid peptide | Zinc- and chloride-dependent metallopeptidase(1277aa) |
Zinc-dependent membrane-bound aminopeptidase |
Zinc-dependent membrane-bound aminopeptidase |
Subcellular localization | Cytoplasm Nucleus Mitochondria |
Cytoplasm Nucleus Mitochondria Endoplasmic reticulum |
Cytoplasm | Cytoplasm |
Cell type | Adrenal glands, brain and heart |
Mesangial, smooth muscle and endothelial cells |
Brain Kidney |
Brain Kidney |
Mesangial, smooth muscle and endothelial cells |
||||
Function | Mitochondrial bioenergetics |
Peptide modification | Unknown | Unknown |
Junctional conductance | ||||
Apoptosis calcium influx | ||||
Pathology | Fluid homeostasis and BP regulation |
Genetic hypertension | Unknown | Unknown |
BP, blood pressure.