Figure 1.

In late response to DNA damage, c-Abl is activated leading to phosphorylation and activation of p73 (p73Y99-p)^{8, 9, 10} and YAP (YAPY357-p)¹² resulting in cell apoptosis. Reuven et al.¹ demonstrate that upon exposure of dense cells to ionizing radiation, activated LATS2 phosphorylates c-Abl, hence inhibiting its kinase function and resulting in reduced p73Y99-p and YAPY357-p-mediated apoptosis leading to cytoprotection. According to this model, LATS2-mediated phosphorylation of YAP at S127 sequesters YAP in the cytoplasm, thus YAP could not function as co-activator of p73 to enhance apoptosis,¹⁸ thereby contributing also to cytoprotection