Table 6.
Analysis of simulated data
| |
Genotypes |
Alleles |
Hardy-Weinberg |
||||||
|---|---|---|---|---|---|---|---|---|---|
| |
|
|
Case |
Control |
|||||
| p G | e G | p A | e A | p HW | e HW | p HW | e HW | ||
|
Genotypic Homogeneity | |||||||||
| 1 |
0.408 |
0.773 |
0.197 |
0.189 |
0.786 |
0.540 |
0.832 |
0.819 |
0.971 |
| 2 |
0.588 |
0.897 |
0.648 |
0.684 |
0.997 |
0.030 |
0.090 |
0.001 |
0.002 |
| 3 |
0.478 |
0.826 |
0.483 |
0.510 |
0.980 |
0.496 |
0.793 |
0.035 |
0.119 |
| 4 |
0.912 |
0.996 |
0.709 |
0.689 |
0.997 |
0.172 |
0.377 |
0.122 |
0.287 |
| 5 |
0.836 |
0.985 |
0.578 |
0.554 |
0.985 |
0.224 |
0.464 |
0.170 |
0.378 |
| 6 |
0.989 |
1.000 |
0.926 |
0.903 |
1.000 |
0.000 |
0.000 |
0.000 |
0.000 |
| 7 |
0.187 |
0.494 |
0.100 |
0.068 |
0.498 |
0.027 |
0.081 |
0.044 |
0.124 |
| 8 |
0.652 |
0.929 |
0.444 |
0.416 |
0.953 |
0.338 |
0.626 |
0.104 |
0.257 |
| 9 |
0.620 |
0.916 |
0.510 |
0.494 |
0.976 |
0.192 |
0.422 |
0.761 |
0.955 |
| 10 |
0.565 |
0.888 |
0.923 |
0.912 |
1.000 |
0.001 |
0.003 |
0.057 |
0.153 |
|
Allelic Homogeneity | |||||||||
| 11 |
0.008 |
0.034 |
0.325 |
0.291 |
0.893 |
0.494 |
0.790 |
0.001 |
0.003 |
| 12 |
0.000 |
0.000 |
0.067 |
0.057 |
0.442 |
0.068 |
0.190 |
0.000 |
0.000 |
| 13 |
0.002 |
0.013 |
0.151 |
0.114 |
0.629 |
0.989 |
1.000 |
0.000 |
0.000 |
| 14 |
0.001 |
0.003 |
0.923 |
0.918 |
1.000 |
0.174 |
0.400 |
0.000 |
0.000 |
| 15 |
0.113 |
0.342 |
0.844 |
0.833 |
1.000 |
0.989 |
1.000 |
0.006 |
0.014 |
| 16 |
0.020 |
0.086 |
0.559 |
0.547 |
0.985 |
0.174 |
0.395 |
0.015 |
0.040 |
| 17 |
0.001 |
0.006 |
0.147 |
0.129 |
0.683 |
0.129 |
0.319 |
0.002 |
0.005 |
| 18 |
0.040 |
0.149 |
0.501 |
0.462 |
0.970 |
0.871 |
0.986 |
0.001 |
0.002 |
| 19 |
0.026 |
0.106 |
1.000 |
1.000 |
1.000 |
0.760 |
0.955 |
0.000 |
0.000 |
| 20 |
0.001 |
0.002 |
0.446 |
0.379 |
0.939 |
0.733 |
0.938 |
0.000 |
0.000 |
|
No Homogeneity | |||||||||
| 21 |
0.000 |
0.000 |
0.925 |
0.928 |
1.000 |
0.000 |
0.000 |
0.015 |
0.045 |
| 22 |
0.843 |
0.987 |
0.646 |
0.618 |
0.993 |
0.055 |
0.153 |
0.141 |
0.333 |
| 23 |
0.062 |
0.219 |
0.104 |
0.124 |
0.661 |
0.989 |
1.000 |
0.007 |
0.028 |
| 24 |
0.669 |
0.939 |
0.403 |
0.408 |
0.955 |
0.994 |
1.000 |
0.621 |
0.882 |
| 25 |
0.000 |
0.000 |
0.000 |
0.000 |
0.003 |
0.000 |
0.000 |
0.771 |
0.958 |
| 26 |
0.105 |
0.331 |
0.017 |
0.047 |
0.403 |
0.001 |
0.001 |
0.001 |
0.001 |
| 27 |
0.000 |
0.000 |
0.000 |
0.000 |
0.012 |
0.072 |
0.197 |
0.010 |
0.033 |
| 28 |
0.180 |
0.485 |
0.230 |
0.233 |
0.835 |
0.310 |
0.598 |
0.324 |
0.602 |
| 29 |
0.134 |
0.387 |
0.068 |
0.045 |
0.389 |
0.045 |
0.128 |
0.063 |
0.170 |
| 30 | 0.807 | 0.980 | 0.522 | 0.517 | 0.980 | 0.806 | 0.971 | 0.713 | 0.933 |
Results of the simulations under three different scenarios: genotypic homogeneity, allelic (but not genotypic) homogeneity and no homogeneity at all. Bold p values indicate incoherence.