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. 2013 Jul 1;8:95. doi: 10.1186/1750-1172-8-95

Table 2.

Frequencies of NK/T-cell Lymphoma, nasal type, and aggressive NK-cell leukemia in previous published series

Series Origin NKTCL ANKCL NKTCL + ANKCL [References]
NK-cell Tumor Study Group *
Asia (Japan)
150 (87.2%)
22 (12.8%)
172 (100%)
[37]
Nasal: 123 (82.0%)
Extranasal: 27 (18.0%)
International Peripheral T-Cell Lymphoma Project (IPTCLP) group**
North America, Europe, and Asia
127 (98.5%)
2 (1.5%)
129 (100%)
[35]
Nasal: 92 (72.4%)
Extranasal: 35 (27.6%)
Brazilian group
South America (Brazil)
120 (100%)
0 (0%)
120 (100%)
[44]
Nasal: 97 (80.8%)
Extranasal: 23 (19.2%)
Intergruppo Italiano Linfomi
Europe (Italy)
26 (100%)
0 (0%)
26 (100%)
[39]
Nasal: 23 (88.5%)
Extranasal: 3 (11.5%)
All series
423 (94.6%)
25 (5.6%)
447 (100%)
NA
Nasal: 335 (79.4%)
    Extranasal: 88 (20.6%)      

Abbreviations: ANKTCL aggressive NK-cell leukemia, NKTCL NK/T-cell Lymphoma, nasal type, NA not applicable.

* Most of the cases presented in this series were from the Japanese survey of NK-cell neoplasms diagnosed between 1994 and 1998, in which 237 cases were registered: 149 nasal-type NK-cell lymphoma (123 nasal and 26 extranasal), 22 aggressive NK-cell leukemia/lymphoma, 19 chronic NK lymphocytosis and 57 cases corresponding to diseases that are not considered as originating from mature NK-cells accordingly to the WHO classification updated in 2008 (11 myeloid/NK-cell precursor acute leukemia, 15 blastic NK-cell lymphoma, 21 precursor NK-cell acute lymphoblastic leukemia) [36].

** Consecutive cases of peripheral T-cell lymphoma (excluding Mycosis Fungoides and Sezary syndrome) and NK/T-cell lymphoma diagnosed between 1990 and 2002. Total number of cases registered: 1153 (Asia: 464, 40.2%; Europe and North America 689, 59.8%). Total number of NK-cell neoplasms registered: 136 (11.8%) (Asia: 104, 76.5%; Europe and North America: 32, 23.5%) (NKTCL: 127; ANKCL: 2; unclassified NK-cell neoplasms: 7).