Table 2.

Cytotoxicity of 6 series against human tumor cell lines

	Fused A-ring			GI50 (μM)a
	X	Y	Z	A549	KB	KBvin	DU145
6a	H	CH	CH	17.8±2.6	15.6±1.3	17.6±2.5	14.8±1.7
6b	Me	CH	N	0.045±0.008	0.091±0.009	0.055±0.010	0.038±0.008
6c	Me	N	N	0.018±0.001	0.011±0.001	0.018±0.004	0.015±0.005
6d	Cl	N	N	0.0017±0.0003	0.0017±0.0008	0.0017±0.0003	0.0015±0.0003
6e	NHMe	N	N	0.027±0.005	0.025±0.002	0.029±0.005	0.023±0.003
Paclitaxel b				0.0076±0.0017	0.0064±0.0014	1.21±0.19	0.006±0.001

^aConcentration of compound that inhibits 50% human tumor cell growth

^bPositive control.