Table 4.

Physicochemical parameters of selected compounds

Compound	at pH 7.4		Human liver microsome t1/2 min
	Water Solubility (μg/mL)	Log P
4f	0.81 ± 0.01	4.02 ± 0.11	ND c
4i	0.16 ± 0.03	4.33 ± 0.12	ND
5f	0.26 ± 0.05	4.75 ± 0.09	ND
6b	3.21 ± 0.60	3.98 ± 0.02	7.89
6c	7.67 ± 0.40	3.65 ± 0.03	25.19
6d	0.45 ± 0.06	4.13 ± 0.05	10.59
6e	7.21 ± 0.06	1.07 ± 0.21	25.97
Propranolola			40.82
Terfenadineb			21.14

Data presented as mean from three separate experiments with or without ± standard deviation (SD).

^aPropranolol has moderate metabolic stability with t_1/2 of 3–5 h in vivo;

^bTerfenadine has fast metabolic stability with t_1/2 of < 3 h in vivo.

^cNot determined.