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. 2013 Aug 30;6:191–196. doi: 10.2147/CCID.S47324

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© 2013 Mahe et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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PROPAGAPATH (Helios Biosciences, Romainville, France) analysis indicates that PKCζ is a potential transducer of the Vitreoscilla filiformis biomass (VFB) activity of Toll-like receptor 2 (TLR2) in skin included in the minimal signaling pathway connecting TLR2 activation to interleukin 8 (IL8) and chemokine (C-C motif) ligand 20 (CCL20) induction.

Abbreviations: FOS, proto oncogene c-Fos; IRAK1, interleukin-1 receptor-associated kinase 1; MYD88, myeloid differentiation primary response gene (88); NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; PML1, promyelocytic leukemia protein-1; PRKCz, protein kinase C, zeta; PRKR, protein kinase R; SP1, specificity protein 1; SRC1, steroid receptor coactivator 1; STAT, signal transducer and activator of transcription; STAT3, signal transducer and activator of transcription 3; TLRAP, toll-interleukin 1 receptor domain containing adaptor protein; TRAF6, tumor necrosis factor receptor-associated factor 6.