Table 5.
Pharmacokinetic parameters (mean ± SD, n = 6)
| Sample | Cmax (pg · mL−1) |
Tmax (min) |
AUC0–360 (min · pg · mL−1) |
Frel |
|---|---|---|---|---|
| Subcutaneous injection (Miacalcin®) | 68 ± 5.14 | 30 | 10,014.60 ± 125.47 | 2.00 |
| Native sCT | 25 ± 3.03 | 60 | 5,004.60 ± 87.64 | 1.00 |
| sCT-CS-NPs | 47 ± 4.45 | 60 | 8,068.80 ± 105.18 | 1.61 |
| sCT-CS-NPs spray dried powders (NPs/M = 30/70) | 56 ± 4.56 | 45 | 8,578.80 ± 98.63 | 1.71 |
| CS-NPs spray dried powders (blank, without sCT loading) | 0.34 ± 1.23 | 360 | 0.697 ± 24.38 | 0.0083 |
Abbreviations: AUC0–360, area under the curve; CS, chitosan; Cmax, maximum plasma concentration; Frel, relative bioavailability; M, mannitol; NPs, nanoparticles; Tmax, time to reach maximum concentration; sCT, salmon calcitonin loaded; SD, standard deviation.