. Author manuscript; available in PMC: 2013 Sep 11.

Published in final edited form as: J Appl Toxicol. 2011 Feb 11;32(2):135–141. doi: 10.1002/jat.1645

Table 1.

In vitro data for novel NSAID-AChEI Conjugates.^*

Compound #	IC₅₀ (μM)	Plasma t_1/2 (min⁻¹)	Clog P^**
20	77.3 ± 9.43	<5	−0.09
21	40.4 ± 3.91	nd	5.87
22	5–15^***	nd	1.37
23	51.8 ±16.9	<5	0.41
24	NA	>12 h	6.38
25	10.6 ±2.2	<5	1.87
26	NA	nd	−0.95
27	35–40^***	>12 h	5.01
28	nd^***	nd	0.50
Galantamine HBr	1.12±0.31		−0.33
Pyridostigmine Mimic (Fig. 2)	NA		−3.49
Neostigmine Mimic (Fig. 2)	4.75 ±0.41		−2.76

NA – not active; nd – not determined.

^**

Clog P calculated using ChemBioDraw Ultra 12.0.

^***

Precise IC₅₀ values could not be obtained due to limits in compound solubility.