Table 2.

% Reduction of Edema and Inflammation Following Exposure to CEES or TPA.^*

Class 1 (Bifunctionals)			Class 2 (Simple Esters)			Class 3 (AChEI Conjugates)
Cmpd #	% Red. (CEES)	% Red. (TPA)	Cmpd #	% Red. (CEES)	% Red. (TPA)	Cmpd #	% Red. (CEES)	% Red. (TPA)
1	20	41**	9	−35	6	20	60**	80***
2	68	17	11	38	73***	22	76***	57**
4	45	70**	12	NA	94**	24	75**	nd
5	91**	21**	13	60**	111***	27	86**	nd
6	62	73***	15	NA	76**
7	90**	24	16	38	47***	NSAID Standards
8	24	31**	18	113**	29**	Diclofenac	17	58***
						Indomethacin	46**	55**
						Ibuprofen	−15	−33
						Naproxen	NS	104**

^*NS – reduction not statistically significant; nd – not determined; NA – not active.

^**Value differs from positive control based on one-way ANOVA, with P < 0.05.

^***Value differs from positive control based on one-way ANOVA, with P < 0.005.