Table 1. Frequency of DNA breakage at RET intron 11, FRA3B, and non-fragile 12p12.3 as detected by LM-PCR.
DNA Breaks/100 ng DNA/Locus (±SD) |
|||
---|---|---|---|
Treatment | RET | FRA3B | 12p12.3 |
Untreated | 0.90 ± 0.50 | 3.75 ± 0.93 | 0.13 ± 0.26 |
0.4 µM APH | 4.08 ± 1.50 | 18.40 ± 2.04 | 0.13 ± 0.26 |
0.4 µM APH + 6 nM BA | 1.25 ± 0.58 | 3.75 ± 1.74 | - |
0.4 µM APH + 3 µM Merbarone | 0.97 ± 0.38 | 5.00 ± 2.80 | - |
0.4 µM APH + 150 nM CPT11 | 23.06 ± 3.75 | 36.98 ± 9.56 | 1.17 ± 0.50 |