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. 2013 Sep 11;8(9):e74533. doi: 10.1371/journal.pone.0074533

Figure 2. Morris water maze test and hippocampal Aβ expression.

Figure 2

A) No differences were detected among three groups of rats in the hidden-platform test on day 1 and day 2. However, rats in Aβ group showed a longer escape latency than rats in ACSF group on days 3-5 and rats in naïve group on day 4-5. ** P<0.01, as compared with ACSF group; # P<0.01, as compared with both naïve and ACSF groups. In contrast, no differences in the escape time in visible-platform test on day 7 and 8. B) Immunohistochemical examination of the hippocampal CA1 area showed a substantially increased reactivity of Aβ1-40/1-42 in Aβ group, whereas Aβ immunoreactivity was barely detectable in rats of naïve and ACSF groups at the same hippocampal site. Scale bar: 100 µm. C) Western blot revealed a significant increase in Aβ expression in hippocampus contralateral to ankle inflammation in rats receiving Aβ injection with or without ankle inflammation. * P<0.05, as compared with contralateral (contra) side of other groups; #P<0.05, as compared with ipsilateral (ipsi) side of remaining groups.