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. 2013 Sep 11;8(9):e74237. doi: 10.1371/journal.pone.0074237

Figure 5. The homeostatic sleep response regulated by NPF signal in males.

Figure 5

(A) Sleep rebound after 12 hour sleep deprivation in wild type flies (yw) is depicted. (B) npf expression was reduced after 12 hour sleep deprivation. (C, D and E) NPF regulated sleep homeostasis, in which C and D are controls for E. Sleep rebound was reduced when npf expression was enhanced (n=19-22 for controls, and n=20 for yw; npf-Gal4/UAS-npf). (F, G and H) NPFR1 regulated sleep homeostasis, in which F and G are controls for H. Sleep rebound was reduced when npfr1 expression was enhanced (n=21-24 for controls, and n=23 for yw; npfr1-Gal4/UAS-npfr1). Error bars and significant differences are as described above. (I) Sleep loss is reduced after sleep deprivation in npf and npfr1 up-regulated lines. (J) Sleep gain/lost ratio is reduced after sleep deprivation in npf and npfr1 up-regulated lines. Error bars and significant difference are as described above.