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. 2013 Sep 11;8(9):e74924. doi: 10.1371/journal.pone.0074924

Figure 6. Rac1 and Cdc42 blockade suppresses tumor growth and prolongs animal survival.

Figure 6

A, Tumor volume curves in 22Rv1 tumor xenograft bearing mice treated with AZA1 or solvent only (Control). *, significantly different from control. B, representative images of human prostate tumor xenografts on day 24 from mice treated with solvent (Control) or 100 µg/day AZA1 (AZA1 d24) (bar  = 1 cm). C, AZA1 significantly suppresses tumor weight of human prostate xenografts in mice. Data are shown as mean tumor weights on day 24. *, significantly different from control on day 24. D, left panel: Representative immunohistochemistry images of tumor tissue sections from mice treated with solvent (Control) or 100 µg/day AZA1 on day 24 stained with Ki-67 antibody (bar  = 200 µm). Cellular proliferation is reduced following Rac1 and Cdc42 blockade. Right panel: Quantitative histomorphometric analysis of Ki-67-positive, proliferating tumor cells. *, significantly different from control. E, effect of AZA1 treatment on animal survival in 22Rv1 prostate cancer bearing mice. AZA1 significantly prolongs animal survival vs. untreated controls.