Table 2. Corresponding fold change in phosphorylation of various receptor tyrosine kinases (RTK’s) in presence and absence of SIM in SH-SY5Y at 6 hrs.
| S. No | p-RTK’s | Fold Change (SIM treated / Untreated) |
|---|---|---|
| 1 | EGF-R | 2.35 |
| 2 | Erb B4 | 1.82 |
| 3 | FGF R2α | 1.67 |
| 4 | FGF R3 | 1.23 |
| 5 | Insulin R | 2.2 |
| 6 | Dtk | 1.3 |
| 7 | MSP R | 2.39 |
| 8 | PDGF Rβ | 1.8 |
| 9 | Flt3 | 2.2 |
| 10 | c-Ret | 1.5 |
| 11 | ROR1 | 3.03 |
| 12 | ROR2 | 1.28 |
| 13 | Tie2 | 2.89 |
| 14 | MuSK | 3.0 |
| 15 | Eph A4 | 2.65 |
| 16 | Eph B2 | 3.09 |
| 17 | Eph B4 | 2.53 |
| 18 | Eph B6 | 2.59 |
The result is average of two experiments. Increased phosphorylation of various RTK’s like EGFR, ErbB4, FGFR2α, Insulin R, Dtk, MSPR, PDGF Rβ, Flt-3, c-Ret, ROR1, ROR2, Tie-2, MUSK, Eph B2, Eph A4, Eph B4 and Eph B6 was observed after SIM treatment. The result is mean of two experiments with standard deviation less than 5%.