Table 1.
Summary of pretreatment demographic and baseline characteristics (intent-to-treat population)
| Placebo (n = 186) |
BUP150 (n = 190) |
BUP300 (n = 188) |
Total (n = 564) |
|
|---|---|---|---|---|
| Country (n) | ||||
| Japan | 149 | 154 | 148 | 451 |
| South Korea | 37 | 36 | 40 | 113 |
| Age (years) | ||||
| Mean | 37.9 | 36.0 | 37.5 | 37.1 |
| SD | 11.09 | 10.42 | 10.96 | 10.84 |
| Median | 37.0 | 35.0 | 36.0 | 36.0 |
| Min | 20 | 18 | 21 | 18 |
| Max | 63 | 64 | 64 | 64 |
| Sex | ||||
| Female | 101 (54%) | 98 (52%) | 105 (56%) | 304 (54%) |
| Male | 85 (46%) | 92 (48%) | 83 (44%) | 261 (46%) |
| Weight (kg) | ||||
| Mean | 60.19 | 61.01 | 62.00 | 61.07 |
| SD | 11.678 | 12.793 | 13.164 | 12.564 |
| Median | 58.45 | 59.00 | 59.95 | 59.00 |
| Min | 37.5 | 39.0 | 38.8 | 37.5 |
| Max | 95.2 | 107.4 | 102.0 | 107.4 |
| DSM-IV-TR diagnosis | ||||
| 296.20 | 1 (<1%) | 0 | 1 (<1%) | 2 (<1%) |
| 296.21 | 0 | 1 (<1%) | 0 | 1 (<1%) |
| 296.22 | 83 (45%) | 84 (44%) | 71 (38%) | 238 (42%) |
| 296.23 | 14 (8%) | 15 (8%) | 11 (6%) | 40 (7%) |
| 296.31 | 0 | 2 (1%) | 0 | 2 (<1%) |
| 296.32 | 81 (44%) | 76 (40%) | 77 (41%) | 234 (41%) |
| 296.33 | 7 (4%) | 12 (6%) | 28 (15%) | 47 (8%) |
| Number of previous depressive episodes (not including current episode) | ||||
| 0 | 98 (53%) | 100 (53%) | 83 (44%) | 281 (50%) |
| 1 | 64 (34%) | 56 (29%) | 71 (38%) | 191 (34%) |
| 2 | 12 (6%) | 22 (12%) | 23 (12%) | 57 (10%) |
| 3 | 8 (4%) | 6 (3%) | 7 (4%) | 21 (4%) |
| 4 or more | 4 (2%) | 6 (3%) | 4 (2%) | 14 (2%) |
| Duration of current major depressive episode(weeks) | ||||
| Mean | 26.8 | 26.5 | 28.7 | 27.3 |
| SD | 19.44 | 19.18 | 22.27 | 20.33 |
| Median | 21.0 | 19.5 | 22.0 | 21.0 |
| Min | 8 | 8 | 8 | 8 |
| Max | 100 | 98 | 101 | 101 |
Notes: DSM-IV TR diagnosis code. 296.2: Major depressive disorder, single episode; 296.3: Major depressive disorder, recurrent.
Abbreviations: BUP150, bupropion SR 150 mg/day (once daily); BUP300, bupropion SR 150 mg/day (twice daily); DSM-IV-TR, Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision; SD, standard deviation; SR, sustained release; Min, minimum; Max, maximum; n, number of subjects.