Table 2. Prognostic accuracy of the four markers by time-dependent ROC curve analyses.

Marker	Peak accuracy (months)	AUC (95%)	Cut-off (%)	Sensitivity	Specificity	PPV(*)
EDN/RB	39 to 55	0.68 (0.57-0.78)	80	0.59	0.77	0.72
p60/CAF-1	21 to 27	0.69 (0.58-0.79)	24	0.69	0.69	0.69
HJURP	28 to 29	0.69 (0.59-0.79)	6	0.92	0.46	0.63
PDLI4	39 to 55	0.65 (0.53-0.78)	20	0.86	0.44	0.61

^(*)PPV : positive predictive value