Table 4. KEGG Orthology enriched for target genes of DE miRNAs between different libraries.

Pathway	LR2/1		LR3/2		LR4/3		LR5/4		LR6/5		LR7/6		LR8/7		LR9/8		LR10/9
	up	down	up	down	up	down	up	down	up	down	up	down	up	down	up	down	up	down
Adherens junction	*	**		*			*	*		*		**		*	**			**
Adipocytokine signaling pathway				*	*				*	*				**	*
Axon guidance	*	**	*	**	*	**	*	**	*	**		**	**	**	**			**
Calcium signaling pathway		*	**							*		**		*	**			**
Chemokine signaling pathway												*			*			*
ErbB signaling pathway		**					**	*		**		**	*	**	**			**
Focal adhesion	**	**		*	**	*		**	**	**		**	**	**	**			**
Gap junction		**		**		**	*	**		**		*		**	**			*
GnRH signaling pathway		**	**	*	*	*	**		*	*		**		**	**			**
Hedgehog signaling pathway		*										*		*	*			*
Insulin signaling pathway		**		**		**	**			**		**		**	**			**
MAPK signaling pathway	**	**		*						**		**		**	**			**
Melanogenesis	**	**	**	**	*	**	**	**		**	**	**	*	**	**			**
mTOR signaling pathway		*								**		*			*			*
Neurotrophin signaling pathway	**	**	**		*	**	**	*		**		**	**	**	**			**
Notch signaling pathway							**
p53 signaling pathway	*				*					*				*	*			*
Phosphatidylinositol signaling system			*			*				**			**		*			*
T cell receptor signaling pathway		**								*		**			**			**
TGF-beta signaling pathway	**	*		**	*			*		**		**	**	**	**			**
VEGF signaling pathway										*
Wnt signaling pathway	**	**		**		*	**	*		**	*	**	**	**	**			**

Asterisk indicated the significant enrichment of KEGG pathways (* p valued <0.05; **p value < 0.01)