Table 3. IL-10 SNPs and risk of ischemic stroke in 1475 participants.
| SNPs | N | cases | % | Odds Ratios (95%CI)* | Odds Ratios (95%CI)# |
|---|---|---|---|---|---|
| rs1800872 | |||||
| Mixed Inheritance Model | |||||
| AA | 615 | 54 | 8.8% | 1.39 (0.72-2.68) | 1.42 (0.73-2.76) |
| AC | 682 | 40 | 5.9% | 0.88 (0.44-1.73) | 0.86 (0.44-1.71) |
| CC | 178 | 12 | 6.7% | 1 | 1 |
| P for trends | 0.124† | 0.104 | 0.072 | ||
| Dominant Inheritance Model | |||||
| AA | 615 | 54 | 8.8% | 1.54 (1.03-2.30) | 1.60 (1.06-2.39) |
| CC+AC | 860 | 52 | 6.0% | 1 | 1 |
| P values | 0.045‡ | 0.036 | 0.024 | ||
| rs1554286 | |||||
| Mixed Inheritance Model | |||||
| TT | 597 | 52 | 8.7% | 1.29 (0.70-2.37) | 1.33 (0.72-2.46) |
| CT | 676 | 39 | 5.8% | 0.79 (0.42-1.48) | 0.79 (0.42-1.48) |
| CC | 202 | 15 | 7.4% | 1 | 1 |
| P for trends | 0.127† | 0.092 | |||
| Dominant Inheritance Model | |||||
| TT | 597 | 52 | 8.7% | 1.54 (1.02-2.30) | 1.59 (1.06-2.39) |
| CC+CT | 878 | 54 | 6.2% | 1 | 1 |
| P values | 0.062‡ | 0.038 | 0.025 | ||
| rs3021094 | |||||
| Mixed Inheritance Model | |||||
| AA | 522 | 28 | 5.4% | 1 | 1 |
| AC | 679 | 47 | 6.9% | 1.31 (0.80-2.14) | 1.33 (0.81-2.17) |
| CC | 274 | 31 | 11.3% | 2.48 (1.44-4.29) | 2.59 (1.49-4.48) |
| P for trends | 0.008† | 0.003 | 0.002 | ||
| Dominant Inheritance Model | |||||
| AA | 522 | 28 | 5.4% | 1 | 1 |
| CC+AC | 953 | 78 | 8.2% | 1.62 (1.03-2.54) | 1.64 (1.04-2.60) |
| P values | 0.045‡ | 0.038 | 0.056 | ||
| Scores of SNPs^ | |||||
| 0 | 412 | 22 | 5.3% | 1 | 1 |
| 1-2 | 584 | 37 | 6.3% | 1.17 (0.67-2.03) | 1.19 (0.68-2.07) |
| 3 | 479 | 47 | 9.8% | 2.08 (1.22-3.55) | 2.16 (1.26-3.70) |
| P for trends | 0.021† | 0.008 | 0.006 |
Odds ratios (95%CI) and p values were calculated by multiple logistic models after adjusting for age, sex, smoking, systolic blood pressure, cholesterol, glucose, and body mass index.
# Odds ratios(95%CI) and p values were calculated by multiple logistic models after adjusting for age, sex, smoking, systolic blood pressure, cholesterol, glucose, body mass index, and IL-10(yes/no top tertile).
† P for trends were calculated by Cochran-Armitage trend test.
P values were calculated by chi-square tests.
Score of SNPs was summary of scores of rs1800872 (if AA, then score=1, if CC+AC, then score=0), rs1554286 (if TT, then score=1, if CC+CT, then score=0), and rs3021094 (if CC+AC, then score=1, if AA, then score=0). Those with score value 1 and 2 were combined into one group in order to increase the statistic power.