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. 2013 Sep 11;8(9):e73759. doi: 10.1371/journal.pone.0073759

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© 2013 Bailey et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Kinetics of tumor growth. (A) Subcutaneous 5TGM1 or KAS 6/1 myeloma tumors were measured by serial caliper measurements following implantation in immunocompetent C57Bl6/KaLwRij or immunocompromised SCID mice respectively. Volume was calculated using the formula (l*h²/2). Tumor growth was fitted using the exponential growth equation Y = Y₀e^(kX), where tumor doubling time was approximately 3.2 and 5.3 days respectively. (B) Kinetics of intratumoral infectious foci expansion based on average infectious focus volume determined by the equation V = where d is the focus diameter (Fig. 1D). Focus expansion was fitted using the exponential growth equation Y = Y₀e^(kX), where focus doubling time was approximately 3.2 hours. (C) Exponential growth rate, doubling time and goodness of fit for approximated growth curves of tumor models and infectious focus expansion. (D) Comparison of infectious foci expansion rate and subcutaneous 5TGM1 of KAS 6/1 myeloma tumor growth rates relative to size of tumor at time of virotherapy administration.

Inline graphic — Kinetics of tumor growth. (A) Subcutaneous 5TGM1 or KAS 6/1 myeloma tumors were measured by serial caliper measurements following implantation in immunocompetent C57Bl6/KaLwRij or immunocompromised SCID mice respectively. Volume was calculated using the formula (l*h²/2). Tumor growth was fitted using the exponential growth equation Y = Y₀e^(kX), where tumor doubling time was approximately 3.2 and 5.3 days respectively. (B) Kinetics of intratumoral infectious foci expansion based on average infectious focus volume determined by the equation V = where d is the focus diameter (Fig. 1D). Focus expansion was fitted using the exponential growth equation Y = Y₀e^(kX), where focus doubling time was approximately 3.2 hours. (C) Exponential growth rate, doubling time and goodness of fit for approximated growth curves of tumor models and infectious focus expansion. (D) Comparison of infectious foci expansion rate and subcutaneous 5TGM1 of KAS 6/1 myeloma tumor growth rates relative to size of tumor at time of virotherapy administration.