Table 5.

Model utility estimates by CD4 count and adverse event

Parameter	Utility	Distributiona	Reference
CD4 count (cells/mm3)		Beta
>500	0.946		16
351 to ≤500	0.933
201 to ≤350	0.931
50 to ≤200	0.853
<50	0.781
Adverse events (disutilities)
CNS symptoms	−0.043		33
Lipid-lowering therapy	0		Expert opinion
Rash	−0.034		33
Renal abnormalities			Expert opinion
No acute kidney injury	0		Expert opinion
Acute kidney injuryb	−0.06		34
Chronic kidney disease with dialysisc	−0.06		34

Notes:

^aDistributions used in probabilistic sensitivity analysis;

^bdisutility is applied in the cycle in which the acute episode occurs;

^cdisutility is applied during cycle of initial diagnosis and all subsequent cycles.

Abbreviation: CNS, central nervous system.