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Predicted effects of deregulated miRNAs in hepatocarcinogenesis. miR-122, miR-199, miR-221 and miR-21 were shown by various studies to be consistently deregulated in HCC. Via aberrant control of protein-coding gene targets (only the major ones are shown), their deregulation is expected to induce biomolecular effects that promote tumorigenesis
Abbreviations: miRNA, microRNA; HCC, hepatocellular carcinoma.
