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. Author manuscript; available in PMC: 2014 Aug 13.
Published in final edited form as: Cancer Lett. 2013 Feb 13;334(1):62–68. doi: 10.1016/j.canlet.2013.02.013

Fig. 1.

Fig. 1

Histopathology of representative colorectal lesions in Swiss Webster mice with AOM/DSS-induced colitis. A) Chronic colitis characterized by thickening of the colonic mucosa, crypt distortion, and chronic inflammation (10× magnification). B) Ulcer in a background of chronic colitis (10× magnification). C) Polypoid colitis-associated dysplasia (4× magnification). Note: The lesion projects above the mucosa (compare to panel D). D) Flat (nonpolypoid) dysplasia. Note: The flat dysplasia (solid arrows) has a contour and thickness similar to that of the adjacent nonneoplastic mucosa (open arrow) (compare to panel C).