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Topology of NOX proteins in phagocytes and nonphagocytes.
Operating as a electron transferases, all NOX protein family members transport electrons from NADPH, generated by the hexose monophosphate shunt, across the plasma or phagosomal membranes in neutrophils and other phagocytes and across the plasma membrane or endosomal membranes in non-phagocytic cells. In neither case do NOX proteins generate O2· directly into the cytoplasm.
